Uses: powerful cognitive enhancement, mental energy
Side Effects: mild headache, sweating, restlessness
Dosage: 4-8mg via sublingual route, up to three times a day
Synergists/Goes Well With: Aniracetam, L-Theanine or Sulbutiamine
The first published study for this member the Racetam derivative family, called Ampakine, was published in 2003. Since then it has become extremely popular for its nootropic effects, which are reported to be significantly stronger than Piracetam and it is included in many modern brain supplements like Max Synapse. As with many newer nootropics, the available information regarding Unifiram is limited. What is known is that is highly effective in terms of improving cognitive function and memory. It is frequently compared to Sunifiram, a slightly older and more affordable Ampakine. Technically speaking, the two share a strong similarity in both chemical structures and mechanisms of action. The basic premise behind Ampakine nootropics is that they improve synaptic transmission between neurons by modifying AMPA receptors, which control the Glutamate uptake in the brain. In addition to improving inter neuron response and communication, it also increases Acetylcholine production. Its affect on Acetylcholine is what makes it often classed with Racetams.
Uses and Benefits
Despite there being a lack of abundant clinical reports, Unifiram is reported to have the same uses and benefits as other, better known Ampakines. These include powerful cognitive enhancements and energy. Some groups claim that Ampakines like Unifiram are hundreds, if not thousands of times stronger than Racetams. While the general pricing and limited availability of many Ampakines, including Unifiram, make it not as widespread in terms of distribution, it is still considered a highly valued nootropic and can be found in a famous brain supplement Max Synapse.
Preliminary studies and limited user reports limit clear data for Unifiram in regards to side effects. Since it is is so very similar to Sunifiram, which is often considered a suitably interchangeable substitute, it can be inferred that the side effects would be similar. In general there are no major reports regarding serious side effects, a consensus among forums and suppliers is that is may have the following: mild headache, sweating and restlessness. A common suggestion among users of Ampakines is that it is best to start with a small dose and gradually work up to avoid any, or severe side effects.
Continuing its comparison to another, very similar Ampakine, the dosage guidelines are: 4mg – 8mg taken via the sublingual route, up to three times a day. Due to the powerful nature of this type of nootropic, and the lack of substantial or long term studies, preliminary findings support that a single dose would never exceed 10mg. It is also strongly advised to not exceed three doses within a twenty four hour period. When first taking Ampakines, research and users suggest starting with the smallest, or half of the smallest dose, and slowly working up to a comfortable dosage within the normal guidelines for dosing.
Synergy and Interactions
Following in accord with information lacking on Unifiram specifically, its extremely close counterpart is commonly stacked with Aniracetam, L-Theanine or Sulbutiamine. Any of these three nootropics can not only further enhance the benefits of Unifiram, they can also provide support for the increased energetic feelings that Ampakines are known for.
In terms of interactions, any supplement should be discussed with a physician prior to being started. The complex, and still not fully understood, nature of many nootropics make them ill advised for some patients. People taking medications to treat cognitive impairment that it is due to dementia, or other cerebrovascular disorders, should always speak with a doctor before beginning any nootropic supplementation. The benefits of these supplements may require medication adjustments in these types of patients.
Anxiolytics are often prescription drugs used to treat acute anxiety. Disorders for which anxiolytics may be prescribed include panic disorder, social phobia, obsessive-compulsive disorder, post-traumatic stress disorder, generalized anxiety disorder, and specific phobias. Nootropics are most commonly used to improve learning, memory, and thinking as proven by Max Synapse. Some nootropics have anxiolytic effects that provide anxiety relief.
Uses and Benefits
Nootropics with anxiolytics effects are good for relaxing the mind, improving mood, and alleviating social anxiety. Phenibut is typically regarded as the best nootropic for anxiety. Aniracetam is said to be effective for easing social anxiety and stress. Noopept has gotten mixed reviews as an anxiolytic—some people report great results while others are not impressed. L-theanine is well known for providing feelings of relaxation and mental clarity. Also called “vitamin B8”, inositol has been reported as being highly useful for alleviating anxiety.
Clinicians believe benzodiazapines—such as alprazolam (Xanax), chlordiazepoxide (Librium), and lorazepam (Ativan)—to be the most frequently prescribed anxiety medications. These drugs operate by honing in on key neurotransmitters in the brain and lowering irregular excitability. They act on the central nervous system to improve sleep, stabilize mood, and ease nervousness and other anxiety symptoms.
The side effects of nootropic anxiolytics vary. For example, aniracetam has been known to cause loss of inhibitions and some users have reported fatigue, mild nausea, and headaches. Phenibut might cause changes in dream sequences, limb pain and numbness, and drowsiness. As with any supplement that is being overused, tolerance and withdrawal are possible.
People who take prescription anxiolytics, especially benzodiazapines, for a long time are prone to developing tolerance, requiring more of the drug to obtain the same level of effectiveness. Studies indicate that alprazolam might be more toxic than other benzodiazapines in overdose and when combined with other drugs. Benzodiazepine withdrawal symptoms include confusion, seizures, rapid breathing, over-responsive reflexes, and rapid heart rate.
Dosage for nootropic anxiolytics depends on the supplement. For example, Phenibut has a daily dosage recommendation of 250mg to 1000mg. For aniracetam, between 750mg and 1500mg is suggested. It is best to start with small doses and increase based on the results. Recommendations for prescription anxiolytics vary as well. For example, alprazolam generally has a daily dosage threshold of 4mg, chlordiazepoxide 100mg, clonazepam 4mg, diazepam 40mg, and lorazepam 10mg. Long-term care patients may have different maximum daily dosages.
Synergy and Interactions
To achieve the desired effects, nootropic users include different supplements in their nootropic stack. For example, if anxiety relief is your goal, add a nootropic with anxiolytic effects to your stack. When deciding which anxiolytic to include, research the different compounds and read user reviews. It is usually best to try various nootropics then determine which ones go well with your stack.
Combining prescription anxiolytics with other central nervous system drugs—such as alcohol, opioids, barbiturates, and tricyclics—can result in respiratory depression and severe over-sedation. Chronic alcohol use with anxiolytics can cause fatal poisoning. Mixing benzodiazepines with lithium or antipsychotic drugs can lead to problems with muscle movement and motor speech. Merging benzodiazepines with clozapine can result in delirium.
You can buy nootropic anxiolytics over the counter or online from Max Synapse, but prescription anxiolytics should be obtained only as advised by a physician.